In my professional opinion...

Tired of downloading terrible games for your iPhone or iPod Touch? Want to know which one are worth your hard-earned money? Then check the Slide To Play Video podcast on iTunes. They have an easy four-point system for you to determine whether a game is worth your hard-earned cash: Avoid, Caution, Good and Must Have. Episodes are between four to nine minutes in length.
On a more humorous note, there is Sock Tube Presents. Using nothing but socks and googly eyes, the creators parody feature films such as Milk, Slumdog Millionaire and Frost/Nixon.

... I'm Lance Boyle, and it doesn't hurt a bit!

Why so serious? Take a look at the comedy podcasts on iTunes. There's Onion News Network, which has been albe to trick people into thinking that it's actual news. CH Originals from CollegeHumor, featuring satire, music videos and series. Then there's the John Cleese podcast, featuring the thoughts, and musings of the acclaimed Monty Python member.

Game On!

I have now come across some game focussed podcasts. For the latest news and rumors, there is the Joystiq podcast, from the creators of the helpful website. For fans of the Halo series, The Bungie Studios podcasts should keep you informed with any news about their upcoming projects. As for the WoW addict, the World of Warcast should help WoW addicts who manage to tear themselves away from the actual game.